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Thymus cDNA library survey uncovers novel features of immune molecules in Chinese giant salamander Andrias davidianus.

Posted by on in 2014
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Zhu R1Chen ZY1Wang J1Yuan JD1Liao XY1Gui JF1Zhang QY2. 2014. Dev Comp Immunol. 46(2):413-22. doi: 10.1016/j.dci.2014.05.019. Epub 2014 Jun 5.

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A ranavirus-induced thymus cDNA library was constructed from Chinese giant salamander, the largest extant amphibian species. Among the 137 putative immune-related genes derived from this library, these molecules received particular focus: immunoglobulin heavy chains (IgM, IgD, and IgY), IFN-inducible protein 6 (IFI6), and T cell receptor beta chain (TCRβ). Several unusual features were uncovered: IgD displays a structure pattern distinct from those described for other amphibians by having only four constant domains plus a hinge region. A unique IgY form (IgY(ΔFc)), previously undescribed in amphibians, is present in serum. Alternative splicing is observed to generate IgH diversification. IFI6 is newly-identified in amphibians, which occurs in two forms divergent in subcelluar distribution and antiviral activity. TCRβ immunoscope profile follows the typical vertebrate pattern, implying a polyclonal T cell repertoire. Collectively, the pioneering survey of ranavirus-induced thymus cDNA library from Chinese giant salamander reveals immune components and characteristics in this primitive amphibian.

Copyright © 2014 Elsevier Ltd. All rights reserved.


Chinese giant salamander Andrias davidianus; Immune gene; Immunoglobulin; Ranavirus-induced; Thymus cDNA library

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