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The study on specific anti-Streptococcus mutans IgY against dental caries in rats

Posted by on in 2003
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 [Article in Chinese]
Hua Xi Kou Qiang Yi Xue Za Zhi. 2003 Oct;21(5):339-41.
Fan M, Jiang Q, Bian Z. Department of Endodontics, College of Stomatology, Wuhan University, Wuhan 430070, China.

OBJECTIVE:
To investigate the effect of specific anti-streptococcus mutans IgY against streptococcus mutans on dental caries development in rats.

METHODS:
35 wistar rats were divided into 5 groups: group A received IgY gargle; group B received IgY lyophilized powder; group C received sterilized water as control; group D and E received egg yolk food with or without specific IgY individually. They were all fed with caries-inducing diet 2000#. The number of caries scores was counted by the procedure of Keyes'.

RESULTS:
There was a significant lower mean of caries scores in groups treated with IgY lyophilized powder and gargle. By treating with egg-yolk food contained specific IgY, the mean of caries scores decreased comparing with no treatment group.

CONCLUSION:
Local passive immunization with specific anti-streptococcus mutans IgY may be an effective way to prevent the development of dental caries.

PMID: 14650981 [PubMed - indexed for MEDLINE].

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