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Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye*

Posted by on in 2003
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Inventors: Taylor, Catherine (Waterloo, CA)  
Cliché, Dominic (Kitchener, CA)  
Heikkila, Elizabeth Margaret (Waterloo, CA)  
Senchyna, Diane Michelle (Waterloo, CA)  
Flanagan, John Gerard (Waterloo, CA)  
Thompson, John E. (Waterloo, CA)  

United States Patent 7381708

Abstract

The present invention provides methods for preventing retinal ganglion cell death in the glaucomatous eye and methods for suppressing apoptosis-specific eIF5A1 expression through the use of antisense oligonucleotides targeted to human apoptosis-specific eIF5A1.

*Note: The custom IgY antibody (Chicken anti-dlF5A1) used in this publication was produced by Gallus Immunotech Inc. 

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