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Overcoming the susceptibility gap between maternal antibody disappearance and auto-antibody production.

Posted by on in 2015
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  • Yosipovich R1Aizenshtein E1Shadmon R1Krispel S1Shuster E1Pitcovski J2. 2015. Vaccine. 33(3):472-8. doi: 10.1016/j.vaccine.2014.10.043. Epub 2014 Nov 4.
  • 1MIGAL - Galilee Technology Center, P.O. Box 831, Kiryat Shmona 11016, Israel.
  • 2MIGAL - Galilee Technology Center, P.O. Box 831, Kiryat Shmona 11016, Israel; Department of Biotechnology, Tel-Hai Academic College, Israel. Electronic address:


In the first 10-14 days of a chick's life, protection is conferred by maternal antibodies. Further broiler protection is achieved by active vaccination. However, the high level of maternal antibodies interferes with the induction of an effective immune response by vaccination at a young age. As a result, there is a gap between the reduction in protective maternal antibodies and elevation of self-produced antibodies following active vaccination. The major aim of this study was to test an approach consisting of passive and active vaccination to overcome this gap and to provide continuous resistance to infectious viral diseases during the broiler's growth period. Newcastle disease virus (NDV), which is one of the world's most prevalent infectious diseases of poultry, was tested as a model. Following subcutaneous injection of 18 hemagglutination-inhibiting (HI) units of anti-NDV immunoglobulin Y per 1-day-old chick, protective log2 antibody titers above 4 could be detected to at least 17 days of age. The combination of passive immunization on day 1 of age with attenuated live vaccination on day 10 led to high protective titers throughout the entire growth period, up to 41 days of age. Moreover, the HI titers in the group of birds immunized with the combined vaccination were significantly more homogeneous than those in the group vaccinated only with live virus. Thus, full protection against NDV of all broilers in flock during their entire growth period was achieved by a vaccination regime that combines passive immunization and live vaccination.

Copyright © 2014 Elsevier Ltd. All rights reserved.


Immunoglobulin Y; Maternal antibody; Newcastle disease virus; Passive immunization

[PubMed - indexed for MEDLINE]
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