Standing out in the field of IgY Immunotechnology

  • Home
    Home A full collection of all the Research Archive entries.
  • Years
    Years Sort entries by year.
  • Tags
    Tags Displays a list of tags that have been used in the blog.
  • Archives
    Archives Contains a list of research entries that were created previously.

Induction of an Fc conformational change by binding of antigen: the generation of protein A-reactive sites in chicken immunoglobulin.

Posted by on in 1975-1979
  • Font size: Larger Smaller
  • Hits: 1515
  • Print

Barkas T, Watson CM
Immunology 1979 Mar 36:557-61

Abstract


Chicken antibody alone does not bind to Staphylococcus aureus or protein A-Sepharose. Immune complexes containing chicken antibodies do bind, however, showing protein A-binding sites exist on the molecules. Binding does not occur via the antigen contained in the complex. Complexes formed in far antigen excess also bind, suggesting that an induced conformational change in the Fc region of the immunoglobulin occurs but only a fraction of the total chicken antibody is reactive.

Last modified on