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IgY antibodies in human nutrition for disease prevention.

Posted by on in 2015
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Müller S1Schubert A1Zajac J1Dyck T2Oelkrug C3,4. 2015.Nutr J. 14:109. doi: 10.1186/s12937-015-0067-3.

  • 1Fraunhofer Institute for Cell Therapy and Immunology (IZI), Perlickstraße 1, 04103, Leipzig, Germany.
  • 2IgY Immune Technologies and Life Sciences Inc., Thunder Bay, Canada.
  • 3Fraunhofer Institute for Cell Therapy and Immunology (IZI), Perlickstraße 1, 04103, Leipzig, Germany. christopher.oelkrug@izi.fraunhofer.de.
  • 4Fraunhofer Project Centre for Biomedical Engineering and Advanced Manufacturing, McMaster University, Hamilton, Canada. christopher.oelkrug@izi.fraunhofer.de.

Abstract

Oral administration of preformed specific antibodies is an attractive approach against infections of the digestive system in humans and animals in times of increasing antibiotic resistances. Previous studies showed a positive effect of egg yolk IgY antibodies on bacterial intoxications in animals and humans. Immunization of chickens with specific antigens offers the possibility to create various forms of antibodies. The use of these alternative therapeutic drugs provides further advantages: (1) The production of IgY's is a non-invasive alternative to current methods; (2) The keeping of chickens is inexpensive; (3) The animals are easy to handle; (4) It avoids repetitive bleeding of laboratory animals; (5) It is also very cost effective regarding the high IgYconcentration within the egg yolk. Novel targets of these antigen specific antibodies are Helicobacter pylori and also molecules involved in signaling pathways in gastric cancer. Furthermore, also dental caries causing bacteria like Streptococcus mutans or opportunistic Pseudomonas aeruginosa in cystic fibrosis patients are possible targets. Therefore, IgY's included in food for human consumption may be able to prevent or cure human diseases.

PMID:
 
26487372
 
[PubMed - in process] 
PMCID:
 
PMC4617726
 
Free PMC Article
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