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Hsp60 specific antibodies in egg yolks from laying hens naturally infected with Salmonella enterica subspecies enterica serovar Enteritidis.

Posted by on in 2003
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Dera-Tomaszewska B, Wysocki J, Kunikowska D, Dziadziuszko H, G?os´nicka R Comp Immunol Microbiol Infect Dis 2003 Jan 26:37-45


Heat shock protein (Hsp) 60 of Salmonella appears to be involved in pathogenesis of infectious processes and host immune responses. Eggs of laying hens from two Salmonella Enteritidis naturally infected flocks (I--acute outbreak of infection; II--occasional bacteria excretion) and one control flock (III) were tested for the presence of yolk antibodies (IgY) against Hsp60 by applying enzyme-linked immunosorbent assay (ELISA). The levels of specific immunoglobulins were related to those against lipopolysaccharide (LPS) and flagellin. the antigens of the established immunological importance in S. Enteritidis infections. Within flock III, the antibody concentrations were consistently low. Elevated levels were detected in eggs from two infected flocks. Levels of specific IgY measured for flock I were higher than those in flock II; the greatest difference was observed for anti-Hsp60. This report indicates a probable important role of Hsp60 as a target of the hens' immune response, especially during the acute phase of S. Enteritidis infection.

Author Address

National Salmonella Centre, Department of Immunology, Institute of Maritime and Tropical Medicine, Powstania Styczniowego 9B, 81-519 Gdynia, Poland.

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