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Effects of maternal exposure to extract of Trichilia catigua on antibody production in the offspring of Wistar rats.

Posted by on in 2017
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Fernandes EV1Ramos AC2Dos Santos AH2Longhini R3Gerardin DCC2Venancio EJ4. Nat Prod Res. 2017 Dec 4:1-4. doi: 10.1080/14786419.2017.1408097. [Epub ahead of print]

a Department of Anatomy , State University of Londrina - UEL , Londrina , Brazil.
b Department of Physiological Sciences , State University of Londrina - UEL , Londrina , Brazil.
c Postgraduate Program in Pharmaceutical Sciences - State University of Maringá - UEM , Maringá , PR , Brazil.
d Department of Pathological Sciences , State University of Londrina - UEL , Londrina , Brazil.


It was evaluated the effects of maternal treatment with the Trichilia catigua (ExTc) crude extract on the antibodies' production by their offspring. Female rats received ExTc or saline from the first day of pregnancy until the twenty-first day after the birth of the pups, when the pups were weaned. All pups were inoculated with two doses of 50 μg of IgY diluted in aluminium hydroxide/PBS on days 26 and 40 of life. Antibody levels were analysed by ELISA. Our results show an increase in levels of IgG1 and IgG2a anti-IgY in female offspring of mothers treated with ExTc compared to female offspring of untreated mothers. Furthermore, ExTc treatment suppressed the production of IgG2a anti-IgY antibodies in males. The data show that maternal exposure to ExTc can modulate the production of antibodies in the offspring.


B cells; Phytotherapic; and gender; immunoglobulin; immunomodulation

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