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Effect of topical anti-Streptococcus mutans IgY gel on quantity of S. mutans on rats' tooth surface.

Posted by on in 2016
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Bachtiar EW1Afdhal A2Meidyawati R3Soejoedono RD4Poerwaningsih E52016. Acta Microbiol Immunol Hung. 63(2):159-69. doi: 10.1556/030.63.2016.2.2.

Department of Oral Biology, Oral Sciences Research Center, Faculty of Dentistry, Universitas Indonesia , Indonesia.
Palapa Dentists, Dental Center , Jakarta, Indonesia.
Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia , Indonesia.
Department of Infectious Diseases and Veterinary Public Health, Faculty of Veterinary Medicine, Bogor Agricultural University , Indonesia.
Department of Pharmacy, Faculty of Medicine, Universitas Indonesia , Indonesia.


This study aims to evaluate the effect of anti-Streptococcus mutans IgY gel on quantity of S. mutans on rats' tooth surface. Sprague Dawley rats were exposed intra-orally with S. mutans Xc and were fed a caries-inducing diet 2000. The 24 rats were divided into four groups: group A had their teeth coated with IgY gel; group B received sterilized water as a control; group C had their teeth coated with IgY gel starting on the 29(th) day; and group D had their teeth coated with a gel without IgY. Plaque samples were swabbed from the anterior teeth for S. mutans colony quantification, and saliva was collected to measure immunoreactivity by enzyme-linked immunosorbent assay. The results indicated that the quantity of S. mutans in rats treated with IgY gel showed significant difference compared with the controls. After coating with IgY anti-S. mutans gel, the mean immunoreactivity in rat saliva was higher than that of the no treatment group. In conclusion, topical application with anti-S. mutans IgY gel reduced the quantity of S. mutans on the tooth surface.


IgY gel; S. mutans; caries

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