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Effect of beta-carotene supplementation on plasma and yolk IgY levels induced by NDV vaccination in Japanese quail

Posted by on in 2003
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 Int J Vitam Nutr Res. 2003 Jul;73(4):285-9.
Kiss Z, Bardos L, Szabo C, Lengyel L, Szabo M.
Department of Animal Physiology and Health, Faculty of Agricultural Sciences, Szent Istvan University, H-2103 Godollo, Pater K. u. 1, Hungary.
maeet@fau.gau.hu.

Abstract

RNewly hatched Japanese quail (Coturnix coturnix japonica) chicks were fed diets containing different levels of retinoids (vitamin A) or beta-carotene. Group A received a commercial diet containing 10,000 IU vitamin A per kilogram. The diets of Groups B, C, and D contained no vitamin A but were supplemented with 1-, 2.5-, and 5-fold retinol equivalents of beta-carotene. Each group contained 16 quails in a 1:1 sex ratio. At 8 weeks of age the quails were immunized orally with Newcastle disease virus (NDV) vaccine according to the manufacturer's recommendations. Boosters were given three times at two-week intervals. Blood samples were taken at two-week intervals until 14 weeks of age. The anti-NDV IgY titre was determined by a locally developed direct enzyme-linked immunosorbent assay (ELISA). Groups A and B showed nearly the same antibody response. This indicates that the preformed vitamin A and the equivalent beta-carotene have the same immunomodulatory effect. Groups receiving higher doses of beta-carotene (Groups C and D) exhibited significantly higher plasma IgY levels compared to Groups A and B. The results indicate that elevated doses of beta-carotene have a slight effect on the adaptive immune response in Japanese quail.

PMID: 12951901 [PubMed - indexed for MEDLINE].

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