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Correlation between adjuvanticity and immunogenicity of cholera toxin B subunit in orally immunised young chickens

Posted by on in 2005
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 Mayo S, Royo F, Hau J.
APMIS. 2005 Apr;113(4):284-7.
Department of Neuroscience, Division of Comparative Medicine, Uppsala University, Uppsala, Sweden.

Abstract

The aim of the present study was to investigate whether the adjuvanticity of the cholera toxin B (CTB) subunit was correlated with its immunogenicity in young orally immunised chickens.

Thirteen 15-day-old chickens were orally immunised with bovine serum albumin (BSA) glutaraldehyde coupled to CTB. The chicken antibody (IgG) concentrations against BSA and CTB, respectively, were quantified by ELISA. A significant positive correlation (r=0.66, n=39, p<0.001) between the concentrations of immunospecific antibodies with specificities against BSA and CTB, respectively, demonstrated that the adjuvanticity of CTB is correlated with its immunogenicity.

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