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Changes in the repertoire of natural antibodies caused by immunization with bacterial antigens.

Posted by on in 2011
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Shilova NVNavakouski MJHuflejt MKuehn AGrunow RBlixt OBovin NV. 2011. Biochemistry (Mosc).76:862-6. doi: 10.1134/S0006297911070170.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.

Abstract

The repertoire of natural anti-glycan antibodies in naïve chickens and in chickens immunized with bacteria Burkholderia mallei, Burkholderia pseudomallei, and Francisella tularensis as well as with peptides from an outer membrane protein of B. pseudomallei was studied. A relatively restricted pattern of natural antibodies (first of all IgY against bacterial cell wall peptidoglycan fragments, L-Rha, and core N-acetyllactosamine) shrank and, moreover, the level of detectable antibodies decreased as a result of immunization.

PMID:
21999548
[PubMed - in process]
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