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Assessment of the reproducibility of random hexapeptide Peptide library-based protein normalization

Posted by on in 2010
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Dwivedi RCKrokhin OVCortens JPWilkins JA.,  2010, J Proteome Res. 9:1144-9.

Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine, University of Manitoba, Winnipeg MB, Canada, R3E 3P4.


The wide dynamic range of proteins in biological samples poses a challenge for the detection of low-abundance proteins. Recently, combinatorial hexapeptide peptide libraries have been suggested as an approach to normalization of proteins in such mixtures. We examined the reproducibility of a commercial hexapeptide ligand library for quantitative and comparative serum proteomic analysis. We also compared this technology with IgY-based affinity depletion.

PMID: 20020779 [PubMed - in process]

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