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Antibodies to the alpha-subunit of insulin receptor from eggs of immunized hens.

Posted by on in 1985-1989
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Song CS, Yu JH, Bai DH, Hester PY, Kim KH
J Immunol 1985 Nov 135:3354-9

Abstract


Simple methods for the generation, purification, and assay of antibodies to the alpha-subunit of insulin receptor from eggs of immunized hens have been described. Chicken antibodies against the alpha-subunit inhibit insulin binding to the receptor and stimulate glucose oxidation as well as autophosphorylation of the beta-subunit. Thus the properties of chicken antibodies are very similar to those of antibodies found in human autoimmune diseases and different from rabbit antibodies obtained against the same antigen.

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