Burns, Volume 29, Issue 7 , November 2003, Pages 649-664
Kathy Q. Zhu (a), Loren H. Engrav (a), Nicole S. Gibran (b), Jana K. Cole (a), Hajime Matsumura (c), Michael Piepkorn (d), F. Frank Isik (a), Gretchen J. Carrougher (a), Paul M. Muangman (b), Murad Y. Yunusov (e) and Tai-Mei Yang (f)
(a) Department of Surgery, Division of Plastic Surgery, Harborview Medical Center, University of Washington, Box 359796, 325 Ninth Avenue, Seattle, WA 98104, USA
(b) Department of Surgery, University of Washington, Seattle, WA, USA
(c) Department of Plastic Surgery, Tokyo Medical University, Tokyo, Japan (d) Department of Pathology, University of Washington, Seattle, WA, USA (e) National Center of Surgery, Tashkent, Uzbekistan
(f) Guangzhou Traumatic Surgery Institute, Guangzhou Red Cross Hospital, Guangzhou, China
Accepted 2 May 2003. ; Available online 28 September 2003.
Abstract
Hypertrophic scarring occurs after deep dermal wounds. Our understanding of the etiology is poor; one reason is the lack of an animal model. In 1972, Silverstein described scarring in the Duroc pig but the model was never confirmed nor disproved. Another reason, as we previously suggested, is that hypertrophic scarring only occurs within regions of human skin that contain cones and the cones have not been studied in relation to hypertrophic scarring. We, therefore (i) explored healing in the female, red Duroc model for similarities to human hypertrophic scarring, studying wound thickness, appearance, healing status at 3 weeks, histology, and immunocytochemical localization of decorin, versican, TGF1 and IGF-1; and (ii) examined Duroc skin for cones. We found that healing after deep wounds in Duroc pigs is similar, but not identical, to human hypertrophic scarring. We also found that Duroc skin contains cones. Healing in the female, red Duroc pig is sufficiently similar to human hypertrophic scarring to warrant further study so that it can be accepted or rejected as a model of human hypertrophic scarring. In addition, the relationship of the cones to hypertrophic scarring needs further detail and can be studied in this model.
Author Keywords: Scar; Porcine; Cone; Burn; Duroc
Corresponding author. Tel.: +1-206-731-3209; fax: +1-206-731-3656.
*1 Presented in part at the American Burn Association, New York, NY 1997, Plastic Surgery Research Council, Galveston, TX 1997, American Burn Association, Lake Buena Vista, FL 1999, Plastic Surgery Research Council, Pittsburgh, PA 1999, Plastic Surgery Research Council, Seattle, WA 2000, Wound Healing Society, Seattle, WA, 2003. |
